Preferred Label : Lipoteichoic Acid;
NCIt synonyms : (2s)-1-({3-O-[2-(Acetylamino)-4-Amino-2,4,6-Trideoxy-Beta-D-Galactopyranosyl]-Alpha-D-Glucopyranosyl}oxy)-3-(Heptanoyloxy)propan-2-Yl
(7z)-Pentadec-7-Enoate; LTA; [(2S)-1-[(2S,3R,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-3-acetamido-5-amino-4-hydroxy-6-methyloxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-heptanoyloxypropan-2-yl]
(E)-pentadec-7-enoate;
NCIt definition : A biologically active lipopolysaccharide-type component of the Gram-negative bacterial
cell wall. Lipoteichoic acid (LTA) may bind to cell surfaces non-specifically, through
interactions with phospholipids, or specifically, through interactions with CD14 or
toll-like receptors (TLR), and then be internalized. Binding to TLR2 may activate
the NFkappaB pathway, mitogen-activated protein kinase (MAPK) signaling pathways and
phosphoinositide 3-kinase (PI3K) activity. This can result in increased expression
of pro-inflammatory cytokines and both pro- and anti-apoptotic genes and may stimulate
expression of the immunosuppressive receptor programmed cell death protein 1 (PD-1;
PDCD1; CD279). Increased expression of PD-1 promotes binding to its ligands, programmed
cell death-1 ligand 1 (PD-L1) or 2 (PD-L2), which stimulates production of the anti-inflammatory
cytokine interleukin-10 (IL-10) and leads to inhibition of CD4-positive T-cell proliferation
and activity. Additionally, LTA also may induce cancer cell proliferation in certain
susceptible tumor cells while having an inhibitory effect on proliferation of other
cancer cells. Lastly, LTA levels in patient samples may also be correlated with inflammatory
damage during acute bacterial infections.;
CAS number : 56411-57-5;
NCI Metathesaurus CUI : CL1905432;
ChEBI ID : CHEBI:28640;
Origin ID : C191976;
UMLS CUI : C0065067;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
