Preferred Label : Anti-LILRB2 Monoclonal Antibody BMS-986406;
NCIt synonyms : Anti-leukocyte Immunoglobulin-like Receptor 2 Monoclonal Antibody BMS-986406;
NCIt related terms : Anti-ILT4 Monoclonal Antibody MK-4830;
NCIt definition : A monoclonal antibody directed against the inhibitory immune checkpoint receptor immunoglobulin-like
transcript 4 (LILRB2; ILT4; leukocyte immunoglobulin-like receptor subfamily B member
2; lymphocyte immunoglobulin-like receptor 2; LIR2; monocyte/macrophage immunoglobulin-like
receptor 10; MIR-10; CD85d), with potential immunomodulating and antineoplastic activities.
Upon administration, anti-LILRB2 monoclonal antibody BMS-986406 targets and binds
to LILRB2. This prevents the binding of LILRB2 ligands to their receptor and prevents
LILRB2-mediated signaling. This abrogates the immunosuppressive activities of LILRB2
in the tumor microenvironment (TME), activates the expression of pro-inflammatory
cytokines, including GM-CSF and tumor necrosis factor alpha (TNFalpha), and enhances
a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. LILRB2, a transmembrane
protein and inhibitory member of the immunoglobulin-like transcript (ILT) family of
proteins, is expressed primarily by myeloid cells, including monocytes, macrophages,
dendritic cells (DCs) and granulocytes, and in certain tumors, and plays a key role
in tumor immune evasion.;
Molecule name : BMS-986406; BMS 986406;
NCI Metathesaurus CUI : CL1905419;
Origin ID : C191955;
UMLS CUI : C5784794;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
