Preferred Label : Anti-CD19-Glucosteroid Receptor Modulator ADC ABBV-31;
NCIt synonyms : Anti-CD19-GRM Antibody-drug Conjugate ABBV-319; Anti-CD19-GRM ADC ABBV-319; ADC ABBV-319;
NCIt definition : An antibody drug conjugate (ADC) composed of an afucosylated immunoglobulin G1 (IgG1)
monoclonal antibody directed against the B-cell-specific membrane protein CD19 conjugated
to a glucocorticoid receptor (GR) modulator (GRM), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CD19-GRM ADC ABBV-319 targets
and binds to CD19. thereby inducing antibody-dependent cellular cytotoxicity (ADCC).
Additionally, by delivering the GRM payload directly to CD19-expressing tumor cells,
ABBV-319 inhibits the activation of GR-dependent expression of proliferative and anti-apoptotic
genes. This induces apoptosis and inhibits tumor cell proliferation in CD19-expressing
tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell
lineage malignancies and drives B-cell proliferation. GRMs show robust anti-tumor
activity against B-cell malignancies.;
Molecule name : ABBV-319; ABBV 319;
NCI Metathesaurus CUI : CL1905147;
Origin ID : C191850;
UMLS CUI : C5784741;
Semantic type(s)
- concept_is_in_subset
- has_target
