Preferred Label : EGFR Mutant-selective Inhibitor NX-019;
NCIt synonyms : EGFR Inhibitor NX-019;
NCIt definition : An orally bioavailable, central nervous system (CNS)-penetrating, mutant-selective
epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.
Upon oral administration, EGFR mutant-selective inhibitor NX-019 targets, binds to,
and inhibits the activity of EGFR mutations, including exon 19 deletions, L858R, T790M,
exon 20 insertions, and certain other mutations, thereby preventing EGFR-mediated
signaling, which induces cell death and inhibits tumor growth in EGFR mutant-overexpressing
tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays
a key role in tumor cell proliferation and tumor vascularization. NX-019 is selective
for mutant EGFR over wild-type EGFR.;
Molecule name : NX 019; NX-019;
NCI Metathesaurus CUI : CL1905148;
Origin ID : C191849;
UMLS CUI : C5784740;
Semantic type(s)
- concept_is_in_subset
- has_target
