NFE2L2/KEAP1/CUL3 Mutant-targeting Agent MGY825

Preferred Label : NFE2L2/KEAP1/CUL3 Mutant-targeting Agent MGY825;

NCIt definition : An antineoplastic agent targeting mutant forms of nuclear factor erythroid 2-related factor 2 protein (NFE2L2), Kelch-like ECH-associated protein 1 (KEAP1), and Cullin-3 (CUL3), with potential antineoplastic activity. Upon administration, NFE2L2/KEAP1/CUL3 mutant-targeting agent MGY825 inhibits the activity of NFE2L2, KEAP1 and CUL3 mutant forms, thereby halting the proliferation of NFE2L2, KEAP1, and CUL3 mutant-expressing tumor cells. NFE2L2/KEAP1/CUL3 are mutated in certain tumor cell types.;

Molecule name : MGY 825; MGY-825;

NCI Metathesaurus CUI : CL1905187;

Details

Origin ID

C191773;

UMLS CUI

C5784723;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Cullin-3 [NCIt concept]
- Kelch-Like ECH-Associated Protein 1 [NCIt concept]
- Nuclear Factor Erythroid 2-Related Factor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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