Preferred Label : Anti-DLL3 CAR-NK Cells;
NCIt synonyms : DLL3-CAR-NK Cells; DLL3-CAR-Natural Killer Cells;
NCIt definition : A preparation of natural killer (NK) cells engineered to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) delta-like protein
3 (DLL3), with potential immunomodulating and antineoplastic activities. Upon administration,
the anti-DLL3 CAR-NK cells recognize, bind to and induce selective cytotoxicity in
DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a
variety of cancer cell types. It plays a key role in embryonic development and in
tumor initiation and proliferation.;
NCI Metathesaurus CUI : CL1799291;
Origin ID : C190818;
UMLS CUI : C5783946;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
