NCIt definition : The hydrochloride salt form of fostroxacitabine bralpamide, a liver-targeting nucleotide
phosphoramidate prodrug of troxacitabine monophosphate (TRX-MP), a dioxolane derivative
and L-configuration deoxycytidine analogue, with potential antineoplastic activity.
Upon oral administration, fostroxacitabine bralpamide is rapidly and specifically
hydrolyzed in hepatocytes by liver carboxylesterase 1 (carboxylesterase 1, CE-1),
generating high levels of the chain-terminating nucleotide, troxacitabine triphosphate
(TRX-TP) in the liver. TRX-TP is then incorporated into tumor cell DNA, leading to
termination of DNA synthesis and inhibition of tumor cell proliferation.;
Semantic type(s)