Preferred Label : Fostroxacitabine Bralpamide Hydrochloride;
NCIt synonyms : Troxacitabine Nucleotide Prodrug MIV-818 Hydrochloride; Troxacitabine Prodrug MIV-818 Hydrochloride; MIV818 Hydrochloride; MIV-818 Hydrochloride; MIV 818 Hydrochloride;
NCIt definition : The hydrochloride salt form of fostroxacitabine bralpamide, a liver-targeting nucleotide
phosphoramidate prodrug of troxacitabine monophosphate (TRX-MP), a dioxolane derivative
and L-configuration deoxycytidine analogue, with potential antineoplastic activity.
Upon oral administration, fostroxacitabine bralpamide is rapidly and specifically
hydrolyzed in hepatocytes by liver carboxylesterase 1 (carboxylesterase 1, CE-1),
generating high levels of the chain-terminating nucleotide, troxacitabine triphosphate
(TRX-TP) in the liver. TRX-TP is then incorporated into tumor cell DNA, leading to
termination of DNA synthesis and inhibition of tumor cell proliferation.;
UNII : UT9O7QSO74;
CAS number : 2416950-25-7;
NCI Metathesaurus CUI : CL1799385;
Origin ID : C190747;
UMLS CUI : C5783902;
Semantic type(s)
- concept_is_in_subset
