Preferred Label : Fostroxacitabine Bralpamide;
NCIt synonyms : Troxacitabine Prodrug MIV-818; Troxacitabine Nucleotide Prodrug MIV-818;
NCIt definition : A liver-targeting nucleotide phosphoramidate prodrug of troxacitabine monophosphate
(TRX-MP), a dioxolane derivative and L-configuration deoxycytidine analogue, with
potential antineoplastic activity. Upon oral administration, fostroxacitabine bralpamide
is rapidly and specifically hydrolyzed in hepatocytes by liver carboxylesterase 1
(carboxylesterase 1, CE-1), generating high levels of the chain-terminating nucleotide,
troxacitabine triphosphate (TRX-TP) in the liver. TRX-TP is then incorporated into
tumor cell DNA, leading to termination of DNA synthesis and inhibition of tumor cell
proliferation.;
UNII : Q1I6YZ0NGF;
CAS number : 2129993-56-0;
Molecule name : MIV 818; MIV-818;
NCI Metathesaurus CUI : CL937071;
Origin ID : C157496;
UMLS CUI : C5667176;
Semantic type(s)
- concept_is_in_subset
