NCIt definition : A liver-targeting nucleotide phosphoramidate prodrug of troxacitabine monophosphate
(TRX-MP), a dioxolane derivative and L-configuration deoxycytidine analogue, with
potential antineoplastic activity. Upon oral administration, fostroxacitabine bralpamide
is rapidly and specifically hydrolyzed in hepatocytes by liver carboxylesterase 1
(carboxylesterase 1, CE-1), generating high levels of the chain-terminating nucleotide,
troxacitabine triphosphate (TRX-TP) in the liver. TRX-TP is then incorporated into
tumor cell DNA, leading to termination of DNA synthesis and inhibition of tumor cell
proliferation.;
Semantic type(s)