Lead Pb 212-DOTAM-GRPR1

Preferred Label : Lead Pb 212-DOTAM-GRPR1;

NCIt synonyms : Pb212-DOTAM-GRPR1; 212Pb-DOTAM-GRPR1;

NCIt definition : A radioconjugate consisting of a gastrin-releasing peptide receptor (GRPR)-targeting antagonist conjugated, through a bifunctional, macrocyclic chelating agent DOTAM (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic amide; TCMC), to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212-DOTAM-GRPR1 targets and binds to GRPR-expressing tumor cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to GRPR-expressing tumor cells. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.;

NCI Metathesaurus CUI : CL1799379;

Details

Origin ID

C190732;

UMLS CUI

C5783889;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gastrin-Releasing Peptide Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients