Preferred Label : Anti-CD137/Anti-FAP Bispecific Antibody BI 765179;
NCIt synonyms : Anti-4-1BB/Anti-FAP Bispecific Antibody BI 765179; Anti-CD137/FAP Bispecific Antibody BI 765179; Anti-4-1BB/FAP Bispecific Antibody BI 765179; CD137/FAP Agonist BI 765179; CD137 x FAP Bispecific Antibody BI 765179; 4-1BB x FAP Bispecific Antibody BI 765179;
NCIt definition : A bispecific antibody targeting both CD137 (4-1BB; tumor necrosis factor receptor
superfamily member 9; TNFRSF9) and fibroblast activation protein (FAP), with potential
immunomodulating and antineoplastic activities. Upon administration, anti-CD137/anti-FAP
bispecific antibody BI 765179 targets and binds to both FAP, expressed on cancer-associated
fibroblasts (CAFs) in the tumor stroma, and CD137, expressed on the surface of immune
cells including activated T-lymphocytes, natural killer (NK) cells and dendritic cells
(DCs). The simultaneous binding of FAP and CD137 results in local clustering of FAP-expressing
CAFs and CD137-expressing T-cells in the tumor microenvironment (TME), local immune
cell activation through the promotion of T-cell activation and cytokine release, and
T-cell-mediated anti-tumor immune responses. CD137, a surface glycoprotein of the
tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor
that plays a key role in T-cell proliferation, survival and cytolytic activity. FAP,
a membrane-bound serine protease overexpressed on CAFs, is minimally expressed on
normal, healthy cells.;
Molecule name : BI 765179; BI-765179;
NCI Metathesaurus CUI : CL1799365;
Origin ID : C190717;
UMLS CUI : C5783881;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
