Preferred Label : CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing T-lymphocytes;
NCIt synonyms : CD19R(EQ)28zeta/truncated Human EGFR T-cells; CD19R(EQ)28zeta/EGFRt T-cells; CD19R(EQ)28zeta/EGFRt T Cells;
NCIt definition : A preparation of genetically modified T-cells transduced expressing a chimeric antigen
receptor (CAR) targeting the tumor-associated antigen (TAA) CD19 and containing the
CD28 signaling domain fused to CD3 zeta, and a truncated form of the human epidermal
growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic
activities. Upon intravenous administration, CD19R(EQ)-CD28-CD3zeta-EGFRt-expressing
T-lymphocytes are directed to CD19-expressing tumor cells, thereby inducing a selective
toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface
antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding
domains and tyrosine kinase activity, EGFRt both facilitates in vivo detection of
the administered T-cells and can promote elimination of those cells upon a cetuximab-induced
antibody dependent cellular cytotoxicity (ADCC) response. The costimulatory signaling
domain enhances proliferation of T-cells and antitumor activity. CD19R(EQ) contains
two-point mutations in the immunoglobulin (Ig) G4 Fc spacer region, thereby preventing
recognition of the CAR by Fc gamma receptors (FcgammaRs).;
NCI Metathesaurus CUI : CL1799391;
Origin ID : C190707;
UMLS CUI : C5783872;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
