Topoisomerase-I Inhibitor

Preferred Label : Topoisomerase-I Inhibitor;

NCIt synonyms : Topoisomerase-I Inhibitors;

NCIt definition : Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.;

ChEBI ID : CHEBI:50276;

Details

Origin ID

C1904;

UMLS CUI

C0594374;

Automatic exact mappings (from CISMeF team)
- topoisomerase II inhibitors [MeSH concept]
- topoisomerase II inhibitors [MeSH Descriptor]
Currated CISMeF NLP mapping
- Product containing topoisomerase inhibitor (product) [SNOMED CT concept]
- topoisomerase I inhibitors [MeSH Descriptor]
- topoisomerase I inhibitors [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- topoisomerase I inhibitors [MeSH concept]
- topoisomerase I inhibitors [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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