Methylcrotonoyl-CoA Carboxylase Subunit Alpha, Mitochondrial

Preferred Label : Methylcrotonoyl-CoA Carboxylase Subunit Alpha, Mitochondrial;

NCIt synonyms : 3-Methylcrotonyl-CoA:Carbon Dioxide Ligase Subunit Alpha; 3-Methylcrotonyl-CoA Carboxylase Biotin Containing Subunit; Methylcrotonoyl-CoA Carboxylase 1; MCCC1; 3-Methylcrotonyl-CoA Carboxylase Biotin-Containing Subunit; 3-Methylcrotonyl-CoA Carboxylase 1; EC 6.4.1.4; MCCase Subunit Alpha;

NCIt definition : Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (725 aa, 80 kDa) is encoded by the human MCCC1 gene. This protein plays a role in the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA.;

NCIt note : 3-methylcrotonyl-CoA carboxylase (MCCC) is likely a dodecamer composed of six biotin-containing alpha subunits (MCCC1) and six beta (MCCC2) subunits.;

NCI Metathesaurus CUI : CL358724;

Details

Origin ID

C190385;

UMLS CUI

C4276584;

Automatic exact mappings (from CISMeF team)
- 3-methylcrotonyl-coa carboxylase 1 [OMIM gene]
- methylcrotonyl-CoA carboxylase subunit 1 [HGNC gene]
- methylcrotonyl-CoA carboxylase subunit 1 [ORDO Gene]
OMIM relation
- 3-methylcrotonyl-coa carboxylase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- methylcrotonoyl-CoA carboxylase 1, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- MCCC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrial Matrix [NCIt concept]
gene_product_has_biochemical_function
- ATPase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Valine, Leucine and Isoleucine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Catabolic Process [NCIt concept]
- Metal Ion Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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