Sucrase-Isomaltase, Intestinal

Preferred Label : Sucrase-Isomaltase, Intestinal;

NCIt synonyms : EC 3.2.1.10; SI; EC 3.2.1.48;

NCIt definition : Sucrase-isomaltase, intestinal (1827 aa, 209 kDa) is encoded by the human SI gene. This protein plays a role in the catabolism of sucrose, isomaltose and other dietary oligosaccharides.;

NCIt note : Sucrase-isomaltase, intestinal is proteolytically cleaved when exposed to pancreatic proteases in the intestinal lumen yielding isomaltase (amino acid residues 2-1007; EC 3.2.1.10) and sucrase (amino acid residues 1008-1827; EC 3.2.1.48) However, the sucrase and isomaltase domains remain associated by noncovalent interactions. (UniProt and OMIM);

NCI Metathesaurus CUI : CL1798937;

Details

Origin ID

C190378;

UMLS CUI

C5780715;

Automatic exact mappings (from CISMeF team)
- Stress incontinence [ICD-11 Sub-sub category]
- Sucrase-isomaltase [OMIM gene]
- sucrase-isomaltase [ORDO Gene]
OMIM relation
- Sucrase-isomaltase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- SI Gene [NCIt concept]
gene_product_expressed_in_tissue
- Intestinal Epithelium [NCIt concept]
- Small Intestine [NCIt concept]
gene_product_has_associated_anatomy
- Crypt Epithelium [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Galactose Metabolism Pathway [NCIt concept]
- Starch and Sucrose Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Catabolic Process [NCIt concept]
- Digestion [NCIt concept]
- Hydrolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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