Preferred Label : Sirolimus Topical Gel NPC-12Y;
NCIt synonyms : Topical Sirolimus Gel NPC-12Y;
NCIt definition : A topical gel formulation containing the macrolide sirolimus (rapamycin), with potential
anti-proliferative and chemopreventive activities. Upon topical administration of
sirolimus topical gel PTX-022, sirolimus migrates into the basal keratinocytes and
is internalized by the affected cells. In turn, sirolimus binds to the immunophilin
FK binding protein-12 (FKBP-12) and forms a sirolimus-FKBP-12 complex. This complex
binds to and inhibits the activity of the serine/threonine kinase mammalian target
of rapamycin (mTOR) and the mTOR-mediated signaling pathways, which reduces cellular
proliferation in mTOR-overexpressing cells. Additionally, by inhibiting mTOR, PTX-022
may inhibit translation of mutant keratin mRNAs and the production of mutant keratins
in cells in which mutant keratin genes dysregulate keratinocyte proliferation.;
Molecule name : NPC-12Y; NPC 12Y;
NCI Metathesaurus CUI : CL1798751;
Origin ID : C190151;
UMLS CUI : C5783525;
Semantic type(s)
- concept_is_in_subset
- has_target
