Preferred Label : CD19-targeted CAR T Cells BZ019;
NCIt synonyms : Anti-CD19 CAR T-cells BZ019; Anti-CD19 CAR-T Cells BZ019;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified and transduced
with a non-viral vector expressing a chimeric antigen receptor (CAR) targeting the
tumor-associated antigen (TAA) CD19 and containing, as of yet undisclosed co-stimulatory
signaling domains, with potential immunostimulating and antineoplastic activities.
Upon administration, CD19-targeted CAR T cells BZ019 recognize and bind to CD19-expressing
tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19
antigen is a B-cell-specific cell surface antigen overexpressed in B-cell lineage
malignancies.;
Molecule name : BZ-019; BZ 019;
NCI Metathesaurus CUI : CL1798773;
Origin ID : C190113;
UMLS CUI : C5783501;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
