Preferred Label : Actinium Ac 225 DOTATATE RYZ101;
NCIt synonyms : 225Ac-DOTA-TATE RYZ101; Actinium Ac 225-Dotatate RYZ101;
NCIt definition : A radioconjugate consisting of the somatostatin analog tyrosine-3-octreotate (Tyr3-octreotate
or TATE) labeled, via the macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA), with the alpha-emitting radioisotope actinium Ac 225, with potential
antineoplastic activity. Upon administration of actinium Ac 225 DOTATATE RYZ101, the
TATE moiety targets and binds to SSTRs, with a much higher affinity for type 2 SSTR,
present on the cell membranes of many types of neuroendocrine tumors (NETs). Upon
binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to SSTR-expressing
tumor cells. SSTRs have been shown to be present in large numbers on NETs and their
metastases, while most other normal tissues express low levels of SSTRs.;
Molecule name : RYZ-101; RYZ 101;
NCI Metathesaurus CUI : CL1798557;
Origin ID : C189915;
UMLS CUI : C5706561;
Semantic type(s)
- concept_is_in_subset
- has_target
