Phosphorylated Eukaryotic Translation Initiation Factor 4E-Binding Protein 1

Preferred Label : Phosphorylated Eukaryotic Translation Initiation Factor 4E-Binding Protein 1;

NCIt synonyms : Phospho-eIF4E-Binding Protein 1; pEIF4EBP1; Phospho-EIF4EBP1; P4EBP1;

NCIt definition : A post-translationally modified form of eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) where one or more of the threonine or serine residues are phosphorylated. Phosphorylation of threonine-37 and -46 is dependent on serine/threonine-protein kinase mTOR activity and may be a surrogate marker for tumor growth, cell survival, angiogenesis and metastasis.;

NCI Metathesaurus CUI : CL1798552;

Details

Origin ID

C189912;

UMLS CUI

C5708828;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
related_to_genetic_biomarker
- EIF4EBP1 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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