Preferred Label : HER2 Inhibitor BI 1810631;
NCIt synonyms : HER-2 Inhibitor BI 1810631;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinase human epidermal growth
factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon
oral administration, HER2 inhibitor BI 1810631 covalently binds to and inhibits the
activity of both wild-type and HER2 mutants, including HER2 mutants with exon 20 insertion
(ex20ins) mutations. This prevents HER2-mediated signaling and may lead to cell death
in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase overexpressed on
a variety of tumor cell types, plays an important role in tumor cell proliferation
and tumor vascularization.;
Molecule name : BI-1810631; BI 1810631;
NCI Metathesaurus CUI : CL1798546;
Origin ID : C189906;
UMLS CUI : C5706559;
Semantic type(s)
- concept_is_in_subset
- has_target
