Preferred Label : XPO1 Inhibitor WJ01075;
NCIt definition : An orally bioavailable inhibitor of the nuclear export protein exportin-1 (XPO1; chromosome
region maintenance 1 protein homolog; CRM1), with potential antineoplastic and pro-apoptotic
activities. Upon administration, XPO1 inhibitor WJ01075 targets and binds to XPO1,
and prevents the XPO1-mediated nuclear export of cargo proteins, including tumor suppressor
proteins (TSPs), such as p53, FOXO, p21, and p27. This leads to their selective accumulation
in the nuclei of tumor cells, which restores the nuclear localization and function
of TSPs, and induces apoptosis in tumor cells. XPO1, the major export factor that
transports proteins and RNA from the nucleus to the cytoplasm, is overexpressed in
a variety of cancer cell types while minimally expressed in normal, healthy cells.
The dysregulated export of TSPs into the cytoplasm prevents TSP-initiated apoptosis.
XPO1 overexpression leads to uncontrolled tumor cell proliferation and is associated
with poor prognosis.;
Molecule name : W-J 01075; W J 01075;
NCI Metathesaurus CUI : CL1798642;
Origin ID : C189815;
UMLS CUI : C5706550;
Semantic type(s)
- concept_is_in_subset
- has_target
