ALK-Rearranged Renal Cell Carcinoma

Preferred Label : ALK-Rearranged Renal Cell Carcinoma;

NCIt synonyms : Anaplastic Lymphoma Kinase Rearrangement-Associated Renal Cell Carcinoma; ALK-RCC;

NCIt definition : An extremely rare renal cell carcinoma characterized by the presence of chromosomal translocations involving the chromosome 2p23 breakpoint that result in gene fusions between the anaplastic lymphoma kinase gene (ALK) and various gene partners.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1794133;

Details

Origin ID

C189249;

UMLS CUI

C5706273;

Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Flank Pain [NCIt concept]
- Hematuria [NCIt concept]
Has associated anatomic sites
- Genitourinary System [NCIt concept]
- Kidney [NCIt concept]
- Kidney and Ureter [NCIt concept]
- Urinary System [NCIt concept]
Has cytogenetic abnormalities
- ALK Gene Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Renal Tubular Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Renal Tubule Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Genitourinary System [NCIt concept]
- Kidney [NCIt concept]
- Renal Tubule [NCIt concept]
- Urinary System [NCIt concept]
disease_mapped_to_gene
- ALK Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- ALK Gene [NCIt concept]
- ALK wt Allele [NCIt concept]
- ALKATI Allele [NCIt concept]

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