Preferred Label : Anti-HER3 Dendritic Cell Vaccine;
NCIt synonyms : Anti-HER3 DC1 Vaccine; HER3-primed DC1 Vaccine; HER3-primed DC Vaccine; HER3-primed Dendritic Cell Vaccine; Anti-HER-3 DC Vaccine; Anti-HER3 DC Vaccine;
NCIt definition : A type-1-polarized dendritic cell (DC1)-based cancer vaccine against the tumor-associated
antigen (TAA) human epidermal growth factor receptor 3 (HER3; ERBB3), with potential
immunomodulatory and antineoplastic activities. Upon intratumoral administration of
the anti-HER3 DC vaccine, the immune system gets exposed to HER3, which may stimulate
a potent cytotoxic T-lymphocyte (CTL) response against HER3-positive tumor cells.
This may result in tumor cell death and decreased tumor growth. HER3, a member of
the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is
overexpressed by a variety of cancers.;
NCI Metathesaurus CUI : CL1794189;
Origin ID : C189232;
UMLS CUI : C5708325;
Semantic type(s)
- concept_is_in_subset
- has_target
