Preferred Label : EGFR Mutant-selective Inhibitor HS-10375;
NCIt synonyms : EGFR C797S Inhibitor HS-10375;
NCIt definition : An orally bioavailable, mutant-selective, fourth-generation epidermal growth factor
receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration,
EGFR mutant-selective inhibitor HS-10375 targets, binds to and inhibits the activity
of EGFR with C797S mutations, thereby preventing EGFR-mediated signaling. This may
both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells.
EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role
in tumor cell proliferation and tumor vascularization. HS-10375 inhibits EGFR with
C797S mutations, which prevents covalent bond formation with third-generation EGFR
inhibitors leading to drug resistance.;
Molecule name : HS-10375; HS 10375;
NCI Metathesaurus CUI : CL1794291;
Origin ID : C189085;
UMLS CUI : C5706537;
Semantic type(s)
- concept_is_in_subset
- has_target
