Preferred Label : Anti-CD27 Monoclonal Antibody GEN1053/BNT313;
NCIt definition : A monospecific hexamer-forming antibody, based on the HexaBody technology platform,
directed against the cell surface antigen CD27, with potential immunostimulatory and
antineoplastic activities. Upon administration, anti-CD27 monoclonal antibody GEN1053/BNT313
targets and binds to CD27 expressed on a variety of immune cell types, including most
T-lymphocytes, and forming a hexamer upon binding. This induces CD27-mediated signaling,
and enhances CD27-mediated responses, including the expansion of antigen-activated
T-cells and natural killer (NK) cells. This restores immune function and leads to
a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD27,
a co-stimulatory molecule and member of the tumor necrosis factor receptor superfamily
(TNFRSF), is expressed on T-lymphocytes, memory B-cells and NK cells. It plays an
important role in NK cell-mediated cytolytic activity and T- and B-lymphocyte proliferation
and activation.;
Molecule name : GEN-1053; GEN1053/BNT313; BNT 313; GEN 1053; BNT-313;
NCI Metathesaurus CUI : CL1794261;
Origin ID : C189061;
UMLS CUI : C5706532;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
