Preferred Label : Tixestobart;
NCIt synonyms : Anti-CD27 Monoclonal Antibody GEN1053/BNT313;
NCIt definition : A monospecific hexamer-forming antibody, based on the HexaBody technology platform,
directed against the cell surface antigen CD27, with potential immunostimulatory and
antineoplastic activities. Upon administration, tixestobart targets and binds to CD27
expressed on a variety of immune cell types, including most T-lymphocytes, and forming
a hexamer upon binding. This induces CD27-mediated signaling, and enhances CD27-mediated
responses, including the expansion of antigen-activated T-cells and natural killer
(NK) cells. This restores immune function and leads to a cytotoxic T-lymphocyte (CTL)-mediated
immune response against tumor cells. CD27, a co-stimulatory molecule and member of
the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes,
memory B-cells and NK cells. It plays an important role in NK cell-mediated cytolytic
activity and T- and B-lymphocyte proliferation and activation.;
UNII : F6V3QF5HAK;
CAS number : 2733575-82-9;
Molecule name : GEN-1053; GEN1053/BNT313; BNT 313; GEN 1053; BNT-313;
NCI Metathesaurus CUI : CL1794261;
Origin ID : C189061;
UMLS CUI : C5706532;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
