Preferred Label : Lutetium Lu 177-PSMA-I&T;
NCIt synonyms : 177Lu-labeled PSMA I&T; Lutetium Lu 177 PSMA I&T; Lu-177-PSMA-I&T;
NCIt definition : A radioconjugate composed of PSMA-I&T, a human prostate-specific membrane antigen
(PSMA)-targeting ligand linked, via the bifunctional, macrocyclic chelating agent
1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid (DOTAGA; DOTA-GA),
to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic
activity against PSMA-expressing tumor cells. Upon administration of lutetium Lu 177-PSMA-I&T,
PSMA-I&T targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing
tumor cells are destroyed by 177Lu through the specific delivery of beta particle
radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein,
is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate
tumor cells as well as a variety of other solid tumors.;
NCI Metathesaurus CUI : CL1793922;
Origin ID : C188987;
UMLS CUI : C5557558;
Semantic type(s)
- concept_is_in_subset
- has_target
