Preferred Label : Anti-TROP-2 Antibody-drug Conjugate DB-1305;
NCIt synonyms : ADC DB-1305; DITAC DB-1305; Anti-TROP-2 ADC DB-1305; Anti-TROP-2/Topoisomerase-1 Inhibitor ADC DB-1305; Anti-TROP-2/P1021 ADC DB-1305;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast cell
surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2;
TACSTD2; GA733-1; M1S1) covalently linked, via a cleavable linker containing maleimide
tetrapeptide, to the topoisomerase-1 inhibitor P1021, with potential antineoplastic
activity. Upon administration of the anti-TROP-2 ADC DB-1305, the anti-TROP-2 antibody
targets and binds to TROP-2 expressed on tumor cells. Upon binding and internalization,
the topoisomerase-1 inhibitor P1021 is released, and inhibits DNA topoisomerase-1
activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and
tumor cell apoptosis. This inhibits the proliferation of TROP-2-expressing tumor cells.
TROP-2 is a transmembrane protein overexpressed in various tumors. Its expression
is associated with enhanced tumor aggressiveness, metastasis, drug resistance and
increased tumor cell survival.;
Molecule name : DB-1305; DB 1305;
NCI Metathesaurus CUI : CL1793601;
Origin ID : C188363;
UMLS CUI : C5706496;
Semantic type(s)
- concept_is_in_subset
- has_target
