NCIt definition : A bispecific antibody directed against both ectonucleotide pyrophosphatase/phosphodiesterase
family member 3 (ENPP3, NPP3, B10, PDNP3 CD203c, or PD-IBETA) and the T-cell surface
antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon
administration, anti-ENPP3/anti-CD3 bispecific antibody XmAb819 binds bivalently to
ENPP3 expressed on tumor cells and monovalently to CD3 expressed on T-cells. The resulting
cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against ENPP3-expressing
tumor cells. While normally expressed at low levels on tubules of the kidney cortex
and by some cells in gastrointestinal, adrenal, and endometrial tissues, the type
II transmembrane glycoprotein ENPP3 is overexpressed in various cancers including
most renal neoplasms and some liver cancers. The bivalent binding to ENPP3 and monovalent
binding to CD3 by XmAb819 may allow selective targeting of ENPP3-overexpressing tumor
cells.;
Semantic type(s)