NCIt definition : A bispecific antibody directed against both ectonucleotide pyrophosphatase/phosphodiesterase
family member 3 (ENPP3, NPP3, B10, PDNP3 CD203c, or PD-IBETA) and the T-cell surface
antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon
administration, anti-ENPP3/anti-CD3 bispecific antibody XmAb819 bivalently binds to
ENPP3 expressed on tumor cells and monovalently binds to CD3 expressed on T-cells.
The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response
against ENPP3-expressing tumor cells. While normally expressed at low levels on tubules
of the kidney cortex and by some cells in gastrointestinal, adrenal, and endometrial
tissues, the type II transmembrane glycoprotein ENPP3 is overexpressed in various
cancers including most renal neoplasms and some liver cancers. The bivalent binding
to ENPP3 and monovalent binding to CD3 by XmAb819 may allow selective targeting of
ENPP3-overexpressing tumor cells.;
Semantic type(s)