NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) CD19
and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CD19/CD28 bispecific antibody
RO7443904 targets and binds to both CD28 expressed on T-cells and CD19 expressed on
tumor cells, which crosslinks the T-cells to the tumor cells. This may result in a
potent cytotoxic T-lymphocyte (CTL) response against the CD19-expressing tumor cells.
CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage
malignancies.;
Molecule name : RO 7443904; RG-6333; RG 6333; RO-7443904;
Semantic type(s)