Preferred Label : Anti-CLDN6 Antibody-drug Conjugate DS-9606a;
NCIt synonyms : Anti-CLDN6 ADC DS-9606; Anti-CLDN6 ADC DS-9606a;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) Claudin 6 (CLDN6; CLDN-6) linked to an as of yet
undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration
of anti-CLDN6 ADC DS-9606a, the anti-CLDN6 antibody moiety targets and binds to CLDN6-expressing
tumor cells. Upon binding and internalization, the cytotoxic agent is released and
kills the CLDN6-expressing tumor cells, through an as of yet unknown mechanism of
action. CLDN6, a transmembrane tight-junction protein and embryonic antigen, is overexpressed
on a variety of tumor cells but is not expressed on normal, healthy adult cells.;
Molecule name : DS-9606; DS 9606; DS-9606a; DS 9606a;
NCI Metathesaurus CUI : CL1793061;
Origin ID : C188245;
UMLS CUI : C5706476;
Semantic type(s)
- concept_is_in_subset
- has_target
