NCIt definition : A bispecific antibody directed against both the T-cell surface antigen CD3 and the
tumor-associated antigen (TAA) cadherin-17 (CDH17), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CDH17/anti-CD3 bispecific
antibody ARB202 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and CDH17 on CDH17-expressing
tumor cells, thereby crosslinking tumor cells and CTLs. This activates and redirects
CTLs to CDH17-expressing tumor cells, which results in the CTL-mediated cell death
of CDH17-expressing tumor cells. CDH17, a cell surface adhesion protein, is overexpressed
in a variety of cancer cell types.;
Semantic type(s)