Preferred Label : SHP2 Inhibitor HS-10381;
NCIt definition : An orally bioavailable inhibitor of protein tyrosine phosphatase (PTP) non-receptor
type 11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic
activity. Upon oral administration, SHP2 inhibitor HS-10381 targets, binds to and
inhibits the activity of SHP2. This prevents SHP2-mediated signaling, inhibits MAPK
signaling and prevents growth of SHP2-expressing tumor cells. SHP2, an oncoprotein
overexpressed in a variety of cancer cell types, regulates cell survival, differentiation
and proliferation through activation of the Ras-Raf-MEK-ERK signaling pathway. The
Ras-MAPK pathway is often hyperactivated in cancer cells due to specific mutations
and rearrangements which are dependent on SHP2 for their oncogenic signaling. SHP2
also regulates programmed cell death 1 (PD-1)-mediated signal transduction and is
involved in immune checkpoint modulation.;
Molecule name : HS-10381; HS 10381;
NCI Metathesaurus CUI : CL1792766;
Origin ID : C188117;
UMLS CUI : C5706453;
Semantic type(s)
- concept_is_in_subset
- has_target
