Preferred Label : RAS Inhibitor RMC-6236;
NCIt synonyms : RASMUTLI(ON) Inhibitor RMC-6236; Ras-selective Tri-complex Inhibitor RMC-6236;
NCIt definition : An orally bioavailable inhibitor of the active, guanosine triphosphate (GTP)-bound
form of both wild type and mutant variants of the RAS isoforms, including HRAS, NRAS
and KRAS, with potential antineoplastic activity. Upon oral administration, RAS inhibitor
RMC-6236 binds to an intracellular chaperone protein, cyclophilin A (CypA). The resulting
inhibitory binary complex binds to active, GTP-bound RAS to form a tri-complex. This
tri-complex inhibits RAS-dependent signaling and inhibits the proliferation of tumor
cells in which RAS is overexpressed and/or mutated. RAS plays an important role in
cell signaling, division and differentiation. Mutations of RAS may induce constitutive
signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : RMC-6236; RMC 6236;
NCI Metathesaurus CUI : CL1792828;
Origin ID : C188048;
UMLS CUI : C5706445;
Semantic type(s)
- concept_is_in_subset
- has_target
