" /> Sendegobresib - CISMeF





Preferred Label : Sendegobresib;

NCIt synonyms : BiDAC Degrader CFT8634; Bifunctional Degradation Activating Compound CFT8634; BRD9-targeting Protein Degrader CFT8634; BRD9 Protein Degrader CFT8634; BRD9 Degrader CFT8634;

NCIt definition : An orally bioavailable heterobifunctional protein degrader of bromodomain-containing protein 9 (BRD9; sarcoma antigen NY-SAR-29; rhabdomyosarcoma antigen MU-RMS-40.8), with potential antineoplastic activity. Sendegobresib is comprised of an E3 ligase-binding moiety and a BRD9-binding moiety. Upon oral administration, sendegobresib targets and binds to BRD9 with its BRD9-binding moiety. Upon BRD9 binding, the E3 ligase-binding moiety binds to cereblon (CRBN), a component of the CRL4-CRBN E3 ubiquitin ligase complex, which directs proteins for destruction, resulting in the proteasome-mediated degradation of BRD9. This leads to an inhibition of the growth of tumor cells that rely on BRD9 for survival. BRD9, a component of one form of the Brg/Brahma-Associated Factor (BAF) complex, is needed for the survival of certain cancer cells due to mutations.;

UNII : AW8PEP3VZ3;

CAS number : 2704617-96-7;

Molecule name : CFT 8634; CFT-8634;

NCI Metathesaurus CUI : CL1792374;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
04/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.