" /> BRD9 Degrader CFT8634 - CISMeF





Preferred Label : BRD9 Degrader CFT8634;

NCIt synonyms : BiDAC Degrader CFT8634; Bifunctional Degradation Activating Compound CFT8634; BRD9-targeting Protein Degrader CFT8634; BRD9 Protein Degrader CFT8634;

NCIt definition : An orally bioavailable heterobifunctional protein degrader of bromodomain-containing protein 9 (BRD9; sarcoma antigen NY-SAR-29; rhabdomyosarcoma antigen MU-RMS-40.8), with potential antineoplastic activity. CFT8634 is comprised of an E3 ligase-binding moiety and a BRD9-binding moiety. Upon oral administration, BRD9 degrader CFT8634 targets and binds to BRD9 with its BRD9-binding moiety. Upon BRD9 binding, the E3 ligase-binding moiety binds to cereblon (CRBN), a component of the CRL4-CRBN E3 ubiquitin ligase complex, which directs proteins for destruction, resulting in the proteasome-mediated degradation of BRD9. This leads to an inhibition of the growth of tumor cells that rely on BRD9 for survival. BRD9, a component of one form of the Brg/Brahma-Associated Factor (BAF) complex, is needed for the survival of certain cancer cells due to mutations.;

Molecule name : CFT 8634; CFT-8634;

NCI Metathesaurus CUI : CL1792374;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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