Preferred Label : Anti-CD19 Antibody-drug Conjugate IKS03;
NCIt synonyms : Anti-CD19 ADC IKS03; Anti-CD19/PBD ADC IKS03;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the tumor-associated antigen (TAA) CD19 (cluster of differentiation 19), that
is site-specifically conjugated with a tumor-cleavable beta-glucuronide linker to
a tumor-cleavable prodrug of pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic
activity. Upon intravenous administration, the monoclonal antibody moiety of anti-CD19
ADC IKS03 targets and binds to CD19 expressed on tumor cells. Upon binding and internalization,
both the linker and prodrug are selectively cleaved by lysosomal b-glucuronidase overexpressed
in tumor cells. Free PBD is released and forms highly cytotoxic DNA interstrand cross-links,
thereby blocking cell division and killing CD19-expressing cancer cells. CD19 antigen
is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.;
Molecule name : LCB 73; IKS 03; IKS-03; LCB-73;
NCI Metathesaurus CUI : CL1792337;
Origin ID : C187655;
UMLS CUI : C5706424;
Semantic type(s)
- concept_is_in_subset
- has_target
