Preferred Label : Anti-CD19-CAR CMV-specific T-lymphocytes;
NCIt synonyms : Anti-CD19-CAR CMV-specific T-cells; CMV-specific CD19-CAR T Cells; CMV-specific CD19 CAR-T Cells;
NCIt definition : A preparation of human cytomegalovirus (CMV)-specific T-lymphocytes that have been
engineered to express a chimeric antigen receptor (CAR) specific for the human tumor
associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CD19-CAR CMV-specific T-lymphocytes recognize,
bind to, and induce selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell
specific cell surface antigen overexpressed in B-cell lineage malignancies. The anti-CD19-CAR
CMV-specific T-lymphocytes may potentially be expanded in vivo through CMV vaccination.;
NCI Metathesaurus CUI : CL1792418;
Origin ID : C187649;
UMLS CUI : C5707273;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
