Preferred Label : Pegylated TOP1 Inhibitor PEEL-224;
NCIt synonyms : Topoisomerase-I Inhibitor PEEL-224;
NCIt definition : A pegylated camptothecin derivative, with potential antineoplastic activity. Upon
administration of pegylated TOP1 inhibitor PEEL-224, camptothecin reaches the tumor
cells and selectively stabilizes covalent topoisomerase I-DNA complexes, which results
in single-stranded and double-stranded DNA breaks, the inhibition of DNA replication,
and the induction of apoptosis. Pegylation allows for increases in half-life and the
exposure time for tumor cells, while decreasing both blood plasma concentrations and
exposure to off-target organs. This may increase efficacy and reduce systemic toxicities.;
Molecule name : PEEL-224; PEEL 224;
NCI Metathesaurus CUI : CL1792160;
Origin ID : C187348;
UMLS CUI : C5706412;
Semantic type(s)
- concept_is_in_subset
- has_target
