Anti-TROP2 Antibody-drug Conjugate BL-M02D1

Preferred Label : Anti-TROP2 Antibody-drug Conjugate BL-M02D1;

NCIt synonyms : Anti-TROP2 ADC BL-M02D1;

NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-TROP2 ADC BL-M02D1, the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the TROP2-expressing tumor cells, through an as of yet unknown mechanism of action. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;

Molecule name : BL-M02D1; BL M02D1;

NCI Metathesaurus CUI : CL1792171;

Details

Origin ID

C187333;

UMLS CUI

C5706401;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor-Associated Calcium Signal Transducer 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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