Preferred Label : Anti-TROP2 Antibody-drug Conjugate BL-M02D1;
NCIt synonyms : Anti-TROP2 ADC BL-M02D1;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast
antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated,
via a cathepsin B-cleavable linker, to the camptothecin derivative and topoisomerase
1 inhibitor Ed-04, with potential antineoplastic activity. Upon administration of
anti-TROP2 ADC BL-M02D1, the anti-TROP2 antibody targets and binds to TROP2 expressed
on tumor cells. Upon binding and internalization, Ed-04 is released and inhibits DNA
topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell
cycle arrest and apoptosis in tumor cells expressing TROP2. TROP2 is a transmembrane
protein overexpressed in various tumors. Its expression is associated with enhanced
tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;
Molecule name : BL-M02D1; BL M02D1;
NCI Metathesaurus CUI : CL1792171;
Origin ID : C187333;
UMLS CUI : C5706401;
Semantic type(s)
- concept_is_in_subset
- has_target
