Preferred Label : Anti-TROP2 Antibody-drug Conjugate BIO-106;
NCIt synonyms : Anti-TROP2 ADC BIO-106;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody against tumor-associated
antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal
transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) linked to an as of yet undisclosed
tubulin inhibitor, with potential antineoplastic activity. Upon administration of
anti-TROP2 ADC BIO-106, the anti-TROP2 antibody targets and binds to TROP2 expressed
on tumor cells. Upon binding and internalization, the tubulin inhibitor is released,
and binds to tubulin and inhibits its polymerization. This results in G2/M phase arrest
and apoptosis, and inhibits the proliferation of TROP2-expressing tumor cells. TROP2
is a transmembrane protein overexpressed in various tumors. Its expression is associated
with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor
cell survival.;
Molecule name : BIO 106; BIO-106;
NCI Metathesaurus CUI : CL1792252;
Origin ID : C187313;
UMLS CUI : C5706396;
Semantic type(s)
concept_is_in_subset
has_target