NCIt definition : A humanized agonistic monoclonal antibody directed against tumor necrosis factor receptor
2 (TNFR2; tumor necrosis factor receptor superfamily member 1B; TNFRSF1B), with potential
antineoplastic activity. Upon administration, emunkitug targets and binds to TNFR2
expressed on the surface of CD4 T-cells, CD8 T-cells and natural killer (NK) cells
in the tumor micro-environment (TME), thereby activating CD4 T-cells, CD8 T-cells
and NK cells. This may enhance T-cell- and NK cell- mediated immune responses against
tumor cells. TNFR2, a member of the TNFR family of co-stimulatory molecules, plays
an important role in T-cell co-stimulation.;
Semantic type(s)