NCIt definition : A lipid nanoparticle (LNP) encapsulating nucleoside-modified messenger RNA (mRNA)
encoding for bispecific antibody directed against the tumor-associated antigen (TAA)
Claudin 6 (CLDN6; CLDN-6) and the human T-cell surface antigen CD3, with potential
immunostimulating and antineoplastic activities. Upon administration, mRNA-encoded
anti-CD3/anti-CLDN6 bispecific antibody BNT142 binds to the plasma membrane of cells
and releases the mRNA into the cells. The mRNA is translated and the anti-CD3/anti-CLDN6
bispecific antibody binds to both CD3-expressing T-cells and CLDN6-expressing cancer
cells, thereby crosslinking CLDN6-expressing tumor cells and cytotoxic T-lymphocytes
(CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated
cell lysis of CLDN6-expressing tumor cells. CLDN6, a transmembrane tight-junction
protein and embryonic antigen, is overexpressed on a variety of tumor cells but is
not expressed on normal, healthy adult cells.;
Semantic type(s)