NCIt definition : A monoclonal antibody that is directed against the tumor-associated antigen (TAA)
B-cell activating factor receptor (BAFFR; tumor necrosis factor receptor superfamily
member 13C; TNFRSF13C; BLyS receptor 3; BR3), with potential antineoplastic activity.
Upon administration, anti-BAFFR monoclonal antibody ESG206 binds to and blocks BAFFR.
This prevents BAFFR-mediated signaling and may kill BAFFR-expressing tumor cells.
BAFFR, a protein belonging to the TNF receptor superfamily, is expressed on the surface
of certain types of cancer cells, including B-cell acute lymphoblastic leukemia. It
plays a key role in the regulation of peripheral B-cell survival.;
Semantic type(s)