Preferred Label : DHODH Inhibitor RP7214;
NCIt synonyms : Dihydro-orotate Dehydrogenase Inhibitor RP7214; RP7214; Dihydroorotate Dehydrogenase Inhibitor RP7214;
NCIt definition : An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential
antineoplastic, anti-inflammatory and antiviral activities. Upon oral administration,
DHODH inhibitor RP7214 specifically targets, binds to and prevents the activation
of DHODH, thereby preventing the fourth enzymatic step in de novo pyrimidine synthesis.
This prevents uridine monophosphate (UMP) formation, DNA synthesis, cell division
and cellular proliferation, promotes cell differentiation, causes cell cycle arrest
and induces apoptosis in susceptible tumor cells. In addition, by preventing DHODH
activity in host cells, RP7214 may reduce the ability of certain viruses, such as
SARS-CoV-2, to replicate, thereby reducing viral load and infection. Also, by preventing
pyrimidine synthesis, RP7214 causes anti-inflammatory and immunomodulatory effects
by decreasing the activation and expansion of pro-inflammatory Th1 effectors and promoting
the differentiation of immunomodulatory Th2 cells, and decreasing the production of
various pro-inflammatory cytokines. RP7214 could potentially attenuate the excessive
production of inflammatory cytokines and the cytokine-mediated inflammatory symptoms,
which are seen in certain viral infections. DHODH, a mitochondrial enzyme, catalyzes
the conversion of dihydroorotate (DHO) to orotate in the endogenous synthesis of UMP.;
Molecule name : RP-7214; RP 7214;
NCI Metathesaurus CUI : CL1779250;
Origin ID : C187040;
UMLS CUI : C5565363;
Currated CISMeF NLP mapping
- RP7214 [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- RP7214 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
