Preferred Label : ALK Inhibitor SY-3505;
NCIt synonyms : ALK TKI SY-3505;
NCIt definition : An orally bioavailable, third-generation inhibitor of the receptor tyrosine kinase
(RTK) anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon
oral administration, ALK inhibitor SY-3505 binds to and inhibits ALK wild-type tyrosine
kinase and numerous ALK mutations, including acquired resistance mutations. Inhibition
of ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell
growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily
and plays an important role in nervous system development. ALK dysregulation and gene
rearrangements are associated with a variety of tumor cell types.;
Molecule name : SY-3505; CT 3505; CT-3505; SY 3505;
NCI Metathesaurus CUI : CL1779244;
Origin ID : C187034;
UMLS CUI : C5667095;
- Semantic type(s)
- concept_is_in_subset
- has_target