Preferred Label : Akt-1 Antisense Oligonucleotide WGI-0301;
NCIt synonyms : Akt-1 AS ODN WGI-0301; Akt-1 Antisense ODN WGI-0301;
NCIt definition : A lipid nanoparticle preparation of archexin, a 20-mer antisense (AS) oligodeoxynucleotide
(ODN) against the proto-oncogene Akt, with potential antineoplastic activity. Upon
administration of AS ODN WGI-0301, archexin binds to Akt-1 mRNA, inhibiting translation
of the transcript. Suppression of Akt-1 expression may result in the inhibition of
the phosphatidylinositol 3-kinase (PI3K)/Akt-mediated signaling. This may inhibit
proliferation and induce apoptosis of tumor cells in which Akt-1 is overexpressed.
Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis
and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety
of antineoplastic agents.;
Molecule name : WGI-0301; WGI 0301;
NCI Metathesaurus CUI : CL1779243;
Origin ID : C187033;
UMLS CUI : C5667093;
Semantic type(s)
- concept_is_in_subset
- has_target
