Preferred Label : Pasifolate Exatecan;
NCIt synonyms : FA-CDC ELU001; Folic-acid Functionalized C'Dot-drug-conjugate ELU001; Folate-receptor Alpha-targeting C'Dot-drug Conjugate ELU001; FR-alpha-targeting CDC ELU001; FR-alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001; Folate-receptor Alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001;
NCIt definition : A conjugate composed of folic acid analogs and exatecans covalently bound by linkers
to the ultrasmall silica-based nanoparticle carrier C'Dot, with potential antineoplastic
activity. Upon administration, pasifolate exatecan targets and binds to the human
folate receptor 1 (FOLR1; FR-alpha) on FR-alpha-expressing tumor cells. Upon internalization,
the camptothecin analog exatecan is released via proteolytic cleavage of the linker
and inhibits DNA topoisomerase 1 activity, thereby inhibiting DNA replication and
resulting in cell cycle arrest and apoptosis in tumor cells expressing FR-alpha. FR-alpha
is a high-affinity folate-binding protein and a member of the folate receptor family;
it is overexpressed in various cancer cell types.;
UNII : 9NL385N34R;
CAS number : 2622895-25-2;
Molecule name : ELU-001; EC112002; ELU 001;
NCI Metathesaurus CUI : CL1779263;
Origin ID : C187021;
UMLS CUI : C5667088;
Semantic type(s)
- concept_is_in_subset
- has_target
