Preferred Label : Folate-receptor Alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001;
NCIt synonyms : FA-CDC ELU001; Folic-acid Functionalized C'Dot-drug-conjugate ELU001; Folate-receptor Alpha-targeting C'Dot-drug Conjugate ELU001; FR-alpha-targeting CDC ELU001; FR-alpha-targeting Ultrasmall Silica Nanoparticle-drug Conjugate ELU001;
NCIt definition : A conjugate composed of folic acid analogs and exatecans covalently bound by linkers
to the ultrasmall silica-based nanoparticle carrier C'Dot, with potential antineoplastic
activity. Upon administration of FR-alpha-targeting ultrasmall silica nanoparticle-drug
conjugate ELU001, the folic acid analogs target and bind to the human folate receptor
1 (FOLR1; FR-alpha) on FR-alpha-expressing tumor cells. Following internalization
of ELU001, the camptothecin analog exatecan is released via proteolytic cleavage of
the linker. Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA
replication and resulting in cell cycle arrest and tumor cell apoptosis. FR-alpha
is a high-affinity folate-binding protein and a member of the folate receptor family;
it is overexpressed in various cancer cell types.;
Molecule name : ELU-001; EC112002; ELU 001;
NCI Metathesaurus CUI : CL1779263;
Origin ID : C187021;
UMLS CUI : C5667088;
Semantic type(s)
- concept_is_in_subset
- has_target
