" /> Felmetatug Vedotin - CISMeF





Preferred Label : Felmetatug Vedotin;

NCIt synonyms : Anti-B7-H4 ADC SGN-B7H4V; Anti-B7-H4 Antibody-drug Conjugate SGN-B7H4V;

NCIt definition : An antibody-drug conjugate (ADC) composed of a human immunoglobulin (Ig) G1 monoclonal antibody directed against the T-cell checkpoint ligand B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) linked to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), via a protease-cleavable peptide linker, with potential antineoplastic activity. Upon administration of anti-B7-H4 ADC SGN-B7H4V, the anti-B7-H4 monoclonal antibody moiety targets and binds to B7-H4 expressed on tumor cells. Upon binding, internalization and linker cleavage, MMAE binds to tubulin and inhibits tubulin polymerization, which results in G2/M phase arrest and apoptosis specifically in B7-H4-expressing tumor cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and tumor-associated macrophages (TAMs). It negatively regulates T-cell immune responses. In addition, SGN-B7H4V may also kill B7-H4-expressing tumor cells through antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).;

UNII : VG5Y3A9DFS;

CAS number : 2924808-30-8;

Molecule name : SGN-B7H4V; SGN B7H4V; PF 08046048; PF-08046048;

NCI Metathesaurus CUI : CL1779170;

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31/07/2025


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