Preferred Label : Anti-interleukin-1 Beta Monoclonal Antibody AK114;
NCIt synonyms : Anti-interleukin-1beta Monoclonal Antibody AK114; Anti-IL-1 Beta Monoclonal Antibody AK114; Anti-IL-1b Monoclonal Antibody AK114;
NCIt definition : A monoclonal antibody targeting the human proinflammatory cytokine interleukin-1 beta
(IL-1b), with potential anti-inflammatory, immunomodulating and antineoplastic activities.
Upon administration, anti-IL-1b monoclonal antibody AK114 targets and binds to IL-1b
and prevents the binding of IL-1b to the IL-1 receptor. This inhibits IL-1b-mediated
signaling pathways, and suppresses inflammatory responses, tumorigenesis and angiogenesis
mediated by IL-1b. IL-1b plays a key role in inflammation, which is present in various
disease states including cancers. IL-1b-mediated signaling pathways include MAPK,
cyclooxygenase and nuclear factor kappa B (NF-kB) pathways, which may lead to macrophage
activation, intra-tumoral accumulation of immunosuppressive myeloid cells, and tumor
growth, invasiveness, metastasis, and angiogenesis.;
Molecule name : AK-114; AK 114;
NCI Metathesaurus CUI : CL1778790;
Origin ID : C186652;
UMLS CUI : C5667068;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
