Preferred Label : Anti-LILRB4 Monoclonal Antibody NGM831;
NCIt synonyms : ILT3 Antagonist Antibody NGM831; Anti-ILT3 Monoclonal Antibody NGM831; Anti-ILT-3 Monoclonal Antibody NGM831;
NCIt definition : A monoclonal antibody directed against the myeloid-enriched immune inhibitory receptor
leukocyte immunoglobulin-like receptor B member 4 (LILRB4; ILT3; ILT-3), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-LILRB4
monoclonal antibody NGM831 targets, binds to and blocks LILRB4, thereby preventing
the interaction with its ligands, such as fibronectin, in the tumor microenvironment
(TME). This prevents the activation of LILRB4-mediated downstream signaling pathways.
This may abrogate LILRB4-mediated promotion of myeloid cell immunosuppression and
inhibition of antitumor immunity. This may restore immune function by activating dendritic
cells (DCs) and T-cells, and may promote T-cell-mediated immune responses against
tumor cells. LILRB4, an inhibitory immune receptor highly expressed on tumor-associated
myeloid cells, primarily tolerogenic DCs, myeloid-derived suppressor cells (MDSCs)
and M2 macrophages, functions as an immune checkpoint that negatively regulates DC-
and T-cell activation. It is upregulated in several tumor types and plays an important
role in tumor infiltration, immunosuppression and immune tolerance.;
Molecule name : NGM-831; NGM 831;
NCI Metathesaurus CUI : CL1778876;
Origin ID : C186492;
UMLS CUI : C5667066;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
