Preferred Label : Posterior Fossa Ependymoma, Group B (PFB);
NCIt synonyms : Posterior Fossa Group B (PFB) Ependymoma; Group B Posterior Fossa Ependymoma; Posterior Fossa Group B (PFB) Ependymoma), Adult-Type; Group B Posterior Fossa Ependymoma, Adult-Type; Posterior Fossa Ependymoma, Group B (PFB), Adult-Type;
NCIt definition : A circumscribed ependymoma that arises in the posterior fossa with characteristic
DNA methylation patterns including retention of nuclear H3 p.K28me3 (K27me3) expression,
absence of CpG island hypermethylation, absence of global DNA hypomethylation, and
absence of EZHIP overexpression. Widespread cytogenetic abnormalities are present.
Frequent chromosomal aberrations include loss of 22q, monosomy 6, and trisomy 18.
It occurs in children older than five years and adults and has a relatively good prognosis.;
Neoplastic status : Undetermined;
NCI Metathesaurus CUI : CL1778958;
Origin ID : C186451;
UMLS CUI : C5670549;
Disease may have findings
- Excludes anatomical site(s)
- Has associated anatomic sites
- Semantic type(s)
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_grade
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_may_have_cytogenetic_abnormality
