Loss or Reduction of Nuclear Histone H3 K28me3 Expression

Preferred Label : Loss or Reduction of Nuclear Histone H3 K28me3 Expression;

NCIt synonyms : Loss or Reduction of Nuclear H3K27me3 Expression; Loss or Reduction of Nuclear H3K28me3 Expression;

NCIt definition : A molecular genetic finding indicating the loss or reduction of nuclear histone H3 K28me3 (K27me3) expression in tumor cells.;

NCIt note : Even though the literature refers to lysine 27 methylation or amino acid variation/mutation, RefSeq indicates that the lysine is located at amino acid position 28 in histone H3. (see https://link.springer.com/article/10.1007/s00401-018-1867-2);

NCI Metathesaurus CUI : CL1778974;

Details

Origin ID

C186438;

UMLS CUI

C5670538;

Semantic type(s)
- Finding [UMLS semantic type]
is_finding_of_disease
- Posterior Fossa Ependymoma, Group A (PFA) [NCIt concept]
is_not_finding_of_disease
- Posterior Fossa Ependymoma, Group B (PFB) [NCIt concept]

Keyword's position in hierarchy(ies) :

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